Campbell, thanks for taking the time to look up the route map and posting the link.
As can be seen (and I was really certain I’d seen the #50 bus in the TTC) the route starts at the TTC and then makes a stop at the DTD West Side Transfer Center (I have to guess this is the bus station near Planet Hollywood) before moving on to Sea World and then to its terminus downtown. Depending on where on I Drive the hotel you’re trying to get to is located, you’ve likely got a very long walk ahead of you. If you’re going to involve a taxi at this point, you’re going to be adding on anywhere from $30 - 45 total to taxi in both directions from Sea World to your friend’s hotel.
Maybe renting a car for a day isn’t such a bad idea after all.
Edit: even if you take the bus to the intersection of I Drive and SR 528, you’re still likely to have a long walk in front of you.
The closest Hampton Inn is actually on Universal Blvd, east of International Drive and is about 2.1 miles walking distance from I Drive and 528, which is where the bus turns and heads west to get on I-4 in order to go downtown.
And don’t forget, you can’t just flag down a taxi on the street, you have to call for one to pick you up unless you’re at a hotel with a taxi stand and even then, a taxi often needs to be called.